endstream At Principia Biopharma, a Sanofi company, we are focused on bringing transformative therapies to patients with serious immune-mediated diseases by changing the way small molecules are developed. %PDF-1.7 5 0 obj Sanofi to acquire Principia Biopharma. The company pipeline products include PRN1008 and PRN2246 and PRN1371 under BTK franchise. Our wholly owned BTK inhibitor, rilzabrutinib (formerly known as PRN1008), is currently being developed in three disease indications, pemphigus, immune thrombocytopenia and IgG4-related disease (IgG4 … Further strengthens core R&D areas of autoimmune and allergic diseases. 4 0 obj 2 0 obj Principia is a biopharmaceutical firm engaged in the development of therapies for immune-mediated diseases with unmet medical needs. 1 0 obj PRN2246/SAR442168, our BTK inhibitor for central nervous system diseases, is currently being developed by Sanofi for multiple sclerosis. Principia is bringing transformative therapies to patients with serious immune-mediated diseases by changing the way small molecules are developed. Please call the Commission at 1-800-SEC-0330 for further information on the public reference room. If successful, our medicines have the potential to bring significant therapeutic benefits, limit unintended side effects, improve quality of life for patients and over time modify the course of disease. stream PARIS – September 28, 2020 – Sanofi announced today the successful completion of its acquisition of Principia Biopharma Inc. (“Principia”) for $100 per share in cash. The company’s Bruton tyrosine kinase (BTK) inhibitors will boost Sanofi’s research and development (R&D) efforts across autoimmune diseases area. <> %���� endobj We aim to do this by delivering drugs that have an optimized risk benefit profile with better quality of life and convenience. endobj We will continue to expand development of our molecules and pipeline and may strategically use collaborations and partnerships as a means to maximizing the value of those assets. <>/Metadata 1434 0 R/ViewerPreferences 1435 0 R>> ���� JFIF ` ` �� C endobj Principia Biopharma Inc. at the SEC public reference room at 100 F. Street, N.E., Washington D.C. 20549. ",#(7),01444'9=82. <> Sanofi’s and Principia Biopharma Inc.’s filings with the SEC are also available to the public from X��r����ϖ�YR��F�@f]}�a����fNZn�>K #��A��ul-�6��Y�f;�w=����^K«�|^M7L�,�X���ݏ�-1�#��H��Y��a����f`9�Fw͢k��4���}�ް�������r���U��zH��_�\��RSS��^[u��^���vУI��B����L��fF��/�jxy2��0��Ȅ������yFf�l^���9[_LJb�$�^�x�k��mr���t�n�fR7/�q�$4e6yc� O[�8o��g �h0Ȝ�acf�� All rights reserved. <> x����o�0�ߑ�?�ӔT��>۱%�TJ[��R�2���C��#@��w력[��!%��������K��d�$�@����8���!��P����3ȃV��^�t�L�O#��>{zr�>-��a;GNʗ����>v'8g(��@�Ega@Zf,��.����` O�s�n��b8 ��Ap�T�X:?ڑ���F� c��&^��+ -�� 2�h��BIT =�:(�el\��ﮃ�C8�����4����p�C� F���h.�ܯ�������S��ۃ˨ =ZH��r��"I��:j�0�d��U��M3��#/'�z���$J,|�H���m��i�ʒ 6 0 obj Through our scientific platform, our strategy is to build and advance a pipeline of best-in-class, oral drug candidates to address serious needs in immune-mediated diseases. Oral Immunoproteasome Inhibitor: Inflammation. Its proprietary Tailored Covalency platform enables to design and develop reversible and irreversible covalent small molecule inhibitors with potencies and selectivities. 3 0 obj © 2020 Principia Biopharma. Principia Biopharma Inc is a clinical-stage biopharmaceutical company. Sanofi completes Principia Biopharma Inc. acquisition *Principia Biopharma Inc. is now a wholly owned subsidiary of Sanofi . stream We are also evaluating PRN473 Topical, a reversible covalent BTK inhibitor in a Phase 1 clinical trial for immune-mediated diseases. <> Our wholly owned BTK inhibitor, rilzabrutinib (formerly known as PRN1008), is currently being developed in three disease indications, pemphigus, immune thrombocytopenia and IgG4-related disease (IgG4-RD). <>/XObject<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 720 405] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> $.' endobj Provides full control of brain-penetrant BTK inhibitor SAR442168 in multiple sclerosis (MS), making commercialization more efficient and eliminating future royalty payments. ��=������;��-QO�~s۔M���~_���I��7G">����xER��-�Q��L�#)� S�C�~�R��� Our mission is to make best-in-class medicines to address unmet medical needs by changing the way small molecule drugs are designed. endobj The company is engaged in developing novel therapies for immunology and oncology. PARIS – September 28, 2020 – …
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